Cancer dormancy: from mice to man.

  title={Cancer dormancy: from mice to man.},
  author={Radu Marches and Richard H. Scheuermann and Jonathan W. Uhr},
  journal={Cell cycle},
  volume={5 16},
In this review, we focused on our studies of cancer dormancy in a murine B cell lymphoma and human breast cancer. Lifelong dormancy was induced in syngeneic mice by prior immunization to the idiotype of the tumor cell (TC) Ig before TC challenge. The mice maintained approximately 10(6) lymphoma cells in their spleen throughout their lifetime despite replication of the TCs at a reduced rate. Recurrences occurred randomly. Because of the balance between replication and cell death, we hypothesized… CONTINUE READING


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