Cancer-derived lysophosphatidic acid stimulates differentiation of human mesenchymal stem cells to myofibroblast-like cells.

@article{Jeon2008CancerderivedLA,
  title={Cancer-derived lysophosphatidic acid stimulates differentiation of human mesenchymal stem cells to myofibroblast-like cells.},
  author={Eun Su Jeon and Hyun Jung Moon and Mi Jeong Lee and Hae Young Song and Young Mi Kim and Mong Cho and Dong-Soo Suh and Man-Soo Yoon and Chulhun L. Chang and Jin Sup Jung and Jae Ho Kim},
  journal={Stem cells},
  year={2008},
  volume={26 3},
  pages={789-97}
}
Lysophosphatidic acid (LPA) is enriched in ascites of ovarian cancer patients and is involved in growth and invasion of ovarian cancer cells. Accumulating evidence suggests cancer-associated myofibroblasts play a pivotal role in tumorigenesis through secreting stromal cell-derived factor-1 (SDF-1). In the present study, we demonstrate that LPA induces expression of alpha-smooth muscle actin (alpha-SMA), a marker for myofibroblasts, in human adipose tissue-derived mesenchymal stem cells (hADSCs… CONTINUE READING

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