Cancer chromosomes in crisis

  title={Cancer chromosomes in crisis},
  author={Ronald A. Depinho and Korn{\'e}lia Poly{\'a}k},
  journal={Nature Genetics},
The benign-to-malignant transition in human breast cancer is associated with a marked increase in chromosomal aberrations. A new study suggests that telomere dysfunction and its associated bridge-fusion-breakage cycles may drive this episodic instability, thereby providing aspiring cancer cells with the multiple genetic aberrations needed to achieve a fully malignant state. 

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