Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies

@article{Gibson2006CancerCD,
  title={Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies},
  author={R. Gibson and D. Keefe},
  journal={Supportive Care in Cancer},
  year={2006},
  volume={14},
  pages={890-900}
}
  • R. Gibson, D. Keefe
  • Published 2006
  • Medicine
  • Supportive Care in Cancer
  • BackgroundDiarrhoea and constipation are common toxicities of chemotherapy, and both are poorly understood. They are manifestations of alimentary mucositis, a condition which affects the entire gastrointestinal tract.DiscussionThe absolute percentage of patients that have diarrhoea or constipation as a result of their treatment has yet to be fully defined, although general estimates place 10% of patients with advanced cancer as being afflicted. Although there has been some major progress in… CONTINUE READING

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    A 24-week, (two 12-week stages), randomized, placebo-controlled, double-blind study to evaluate the safety and efficacy of crofelemer in providing prophylaxis of diarrhea in adult… Expand
    ConditionsAdult Solid Tumor, Cancer Therapy-Related Diarrhea, Chemotherapy-related Diarrhea, (+3 more)
    InterventionDrug
    Chemotherapy-induced diarrhoea
    • 44

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 87 REFERENCES
    Mucositis: Its Occurrence, Consequences, and Treatment in the Oncology Setting.
    • 250
    Management of chemotherapy-induced nausea, vomiting, oral mucositis, and diarrhoea.
    • 166
    Constipation in advanced cancer patients
    • 149
    Effect of high-dose chemotherapy on intestinal permeability in humans.
    • 141
    • PDF
    Recommended guidelines for the treatment of cancer treatment-induced diarrhea.
    • 452
    • Highly Influential
    • PDF
    Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans
    • 298
    • Highly Influential
    • PDF
    Recommended guidelines for the treatment of chemotherapy-induced diarrhea.
    • 143
    • Highly Influential