Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies

@article{Gibson2006CancerCD,
  title={Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies},
  author={Rachel Gibson and Dorothy Keefe},
  journal={Supportive Care in Cancer},
  year={2006},
  volume={14},
  pages={890-900}
}
BackgroundDiarrhoea and constipation are common toxicities of chemotherapy, and both are poorly understood. They are manifestations of alimentary mucositis, a condition which affects the entire gastrointestinal tract.DiscussionThe absolute percentage of patients that have diarrhoea or constipation as a result of their treatment has yet to be fully defined, although general estimates place 10% of patients with advanced cancer as being afflicted. Although there has been some major progress in… 

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References

SHOWING 1-10 OF 86 REFERENCES

Management of chemotherapy-induced nausea, vomiting, oral mucositis, and diarrhoea.

Constipation in advanced cancer patients

Constipation is a frequent, distressing, and underestimated complication in patients with advanced cancer. It may develop from general disturbances that may or may not be cancer related, but the use

Effect of high-dose chemotherapy on intestinal permeability in humans.

TLDR
It is concluded that chemotherapy given for malignant disease is associated with a transient abnormality in intestinal sugar permeability, which peaks at 7 days after treatment and is composed of both mono- and di-saccharide absorption abnormalities.

Mucositis: Its Occurrence, Consequences, and Treatment in the Oncology Setting.

TLDR
Mucositis induced by antineoplastic drugs is an important, dose-limiting, and costly side effect of cancer therapy and can also have a significant economic cost in the autologous and allogeneic bone marrow transplant settings for hematologic malignancies.

Management of Chemotherapy-Induced Adverse Effects in the Treatment of Colorectal Cancer

TLDR
Supportive measures for alleviation of the adverse effects of fluorouracil, raltitrexed, irinotecan and oxaliplatin, respectively, are described, based on study results.

Overview of chemotherapy-induced diarrhea.

  • C. Viele
  • Medicine
    Seminars in oncology nursing
  • 2003
TLDR
Through ongoing, regular patient contact, the oncology nurse is uniquely situated to monitor patients for the development of CID, assess its severity, and provide guidance to the health care team on the patient's status.

Control of chemotherapy-induced diarrhoea with octreotide in patients receiving 5-fluorouracil.

The biological basis for the attenuation of mucositis: the example of interleukin-11

TLDR
Interleukin-11, a pleotropic cytokine, has a range of activities which are potentially relevant to mucositis and has been used successfully to modify the development, severity and course of mucosiositis in an animal model which closely mimics the equivalent human condition.

Management of acute cancer treatment-induced diarrhea.

TLDR
Whatever therapy is chosen, the goal must be to quickly control this debilitating and potentially life-threatening side effect so that primary chemotherapy and/or radiation therapy may be resumed and completed.
...