Cancer chemoresistance: the relationship between p53 and multidrug transporters.

@article{Bush2002CancerCT,
  title={Cancer chemoresistance: the relationship between p53 and multidrug transporters.},
  author={Jason A. Bush and Gang Li},
  journal={International journal of cancer},
  year={2002},
  volume={98 3},
  pages={323-30}
}
Extensive studies indicate that both p53 and multidrug transporters play important roles in chemoresistance. Since the initial reports a decade ago demonstrating a transcriptional dependence of the ABCB1 gene (MDR) promoter by p53, much data have been accumulated. However, despite being the subject of intense study, this p53-MDR relationship remains unclear in human cancers. The data are confounded by variable and contrasting results when considering the in vitro regulation and attempting to… CONTINUE READING