• Corpus ID: 26454713

Cancer chemopreventive potential of the Egyptian flaxseed oil in a rat colon carcinogenesis bioassay--implications for its mechanism of action.

@article{Salim2011CancerCP,
  title={Cancer chemopreventive potential of the Egyptian flaxseed oil in a rat colon carcinogenesis bioassay--implications for its mechanism of action.},
  author={Elsayed I. Salim and Ahlam E Abou-Shafey and Ahmed Masoud and Salwa A Elgendy},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2011},
  volume={12 9},
  pages={
          2385-92
        }
}
The possible chemopreventive effects of natural Egyptian flaxseed oil on preneoplasia and cancer formation were investigated in a rat medium-term colon carcinogenesis bioassay. Male Wistar rats were divided into 6 groups. Groups 1, 3 and 5 were initiated by 1,2-dimethylhydrazine (DMH) 20 mg/kg body weight s.c. 8 times, twice a week to initiate colon carcinogenesis. Groups 1 and 3 received 20% or 5% flaxseed oil respectively in diet in post initiation stage until the end. Groups 2 and 4 served… 

Figures and Tables from this paper

Chemopreventive effect of Amorphophallus campanulatus (Roxb.) blume tuber against aberrant crypt foci and cell proliferation in 1, 2-dimethylhydrazine induced colon carcinogenesis.

TLDR
It is indicated that ACME could exert a significant chemopreventive effect on colon carcinogenesis induced by DMH, and amplified expression of PCNA in the colon was clearly noted with initiation, post-initiation and entire period of ACME treatment regimens.

Chemoprotective Efficacy of Curcumin and Flax Seed Oil in 1, 2-Dimethylhydrazine Induced Rat Colon Cancer

TLDR
It is concluded that inhibition of oxidative stress, enhancement of antioxidant status and amelioration of colon tissue by curcumin and flax seed oil suggest their potential efficacy as protective naturally occurring agents against colon carcinogenesis.

Effect of Lactobacillus plantarum LS/07 in combination with flaxseed oil on the microflora, enzymatic activity, and histological changes in the development of chemically induced precancerous growth in the rat colon

TLDR
The total results showed that potentiating effects of natural components were markedly achieved in the experimental group PRO-O, and indicated that L. plantarum LS/07 in combination with flaxseed oil had a positive influence on colon microflora, enzymatic activities, and cytokine activity.

Anticancer potentiality of lignan rich fraction of six Flaxseed cultivars

TLDR
Dietary intake of 10% of Giza 9 Flaxseeds twice daily for 3 weeks in mice-bearing solid Ehrlich ascites carcinoma (EAC) resulted in reducing the tumor volume, the expression of estrogen, insulin growth factor, progesterone, VEGF and MMP-2, but enhanced expression of caspase-3.

α-Linolenic Fatty Acid Supplementation Decreases Tumor Growth and Cachexia Parameters in Walker 256 Tumor-Bearing Rats

TLDR
OI, rich in ALA, caused the same effect on cancer as those seen in FO, andFish oil supplementation increased of threefold of ALA when compared to W (P < 0.05).

Effects of Two Traditional Chinese Cooking Oils, Canola and Pork, on pH and Cholic Acid Content of Faeces and Colon Tumorigenesis in Kunming Mice.

TLDR
Results indicate that cooking oil effects faecal pH, but does not affect the faecic cholic acid content and thus AOM-induced colon neoplastic ACF is modified by dietary fat.

References

SHOWING 1-10 OF 64 REFERENCES

Chemopreventive effect of trans-resveratrol--a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesis.

TLDR
Res is suggested to be an effective chemopreventive agent, which suppresses DMH-induced colon carcinogenesis at various stages, as indicated by optimal concentration of thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH).

Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.

TLDR
Results indicate that dietary sulindac at 160 and 320 ppm levels inhibited the incidence of invasive and noninvasive adenocarcinomas of the colon and suppressed the colon tumor volume in a dose-dependent manner.

Flaxseed supplementation and early markers of colon carcinogenesis.

The Protective Role of Lychnophora ericoides Mart. (Brazilian Arnica) in 1,2-Dimethylhydrazine-Induced Experimental Colon Carcinogenesis

TLDR
Lychnophora ericoides extracts were effective against the development of cancer and suggest that LE has a protective influence on the process of colon carcinogenesis, suppressing both the initiation and the promotion of colonic carcinogenesis.

Anti-carcinogenic properties of omeprazole against human colon cancer cells and azoxymethane-induced colonic aberrant crypt foci formation in rats.

TLDR
Anticancer properties observed in colon cancer cell lines suggest that omeprazole may induce key signaling molecules of antiproliferation and inhibition of anti-apoptotic proteins in a dose-dependent manner.

The effect of dietary fat on the promotion of mammary and colon cancer in a dual-organ rat carcinogenesis model.

TLDR
The main conclusion of the experiment is that the incidence of colon and Mammary cancers increased rapidly when the dietary levels of fat were increased from 15% to 30% of calories and that there was no significant influence on the colon and mammary cancer risk beyond 30%" of calories from fat.

Most Effective Colon Cancer Chemopreventive Agents in Rats: A Systematic Review of Aberrant Crypt Foci and Tumor Data, Ranked by Potency

TLDR
This review gathers most known chemopreventive agents, ranks the most promising agents against colon carcinogenesis in rats or mice, and further supports the use of ACF as a surrogate end point for tumors in rats.

The influence of flaxseed and lignans on colon carcinogenesis and beta-glucuronidase activity.

TLDR
It is concluded that flaxseed has a colon cancer protective effect, that it is due, in part, to SD and that the protective effect of flax Seed is associated with increased beta-glucuronidase activity.

Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci in rat colon by docosahexaenoic acid.

TLDR
It is suggested that DHA suppresses the formation and growth of aberrant crypt foci and has a preventive effect on colon carcinogenesis.
...