Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes.

@article{Gerhuser1997CancerCP,
  title={Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes.},
  author={Clarissa Gerh{\"a}user and M. X. You and Jane Liu and Robert M. Moriarty and M Hawthorne and Rajendra G. Mehta and Richard C. Moon and John M Pezzuto},
  journal={Cancer research},
  year={1997},
  volume={57 2},
  pages={272-8}
}
Chemoprevention involves the use of natural or synthetic substances to reduce the risk of developing cancer. Two dietary components capable of mediating chemopreventive activity in animal models by modulation of drug-metabolizing enzymes are sulforaphane, an aliphatic isothiocyanate, and brassinin, an indole-based dithiocarbamate, both found in cruciferous vegetables. We currently report the synthesis and activity of a novel cancer chemopreventive agent, (+/-)-4-methylsulfinyl-1-(S… CONTINUE READING

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