Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol.

@article{Rimando2002CancerCA,
  title={Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol.},
  author={Agnes M. Rimando and Muriel Cuendet and Cristian Desmarchelier and Rajendra G. Mehta and John M Pezzuto and Stephen O. Duke},
  journal={Journal of agricultural and food chemistry},
  year={2002},
  volume={50 12},
  pages={
          3453-7
        }
}
Pterostilbene, a natural methoxylated analogue of resveratrol, was evaluated for antioxidative potential. The peroxyl-radical scavenging activity of pterostilbene was the same as that of resveratrol, having total reactive antioxidant potentials of 237 +/- 58 and 253 +/- 53 microM, respectively. Both compounds were found to be more effective than Trolox as free radical scavengers. Using a plant system, pterostilbene also was shown to be as effective as resveratrol in inhibiting electrolyte… Expand
Scavenging of hydroxyl radical by resveratrol and related natural stilbenes after hydrogen peroxide attack on DNA.
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It is shown for the first time that methoxylated derivatives of resveratrol are very efficient in reducing DNA damage and the results of DFT calculations in which the three stilbene species scavenge the hydroxyl radical (associated with the H2O2 insult) are described. Expand
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Pterostilbene exhibited strong anti-oxidant activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide in a concentration dependent manner, thereby potentiating its role as an anti- oxidant. Expand
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The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway.
  • C. L. Saw, Yu’e Guo, +4 authors A. Kong
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2014
TLDR
This study demonstrated that the berry constituents quercetin, kaempferol, and pterostilbene activated the Nrf2-ARE signaling pathway and exhibited synergistic anti-oxidative stress activity at appropriate concentrations. Expand
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Interestingly, pterostilbene can induce death in both sensitive and chemoresistant cancer cells by inducing cell cycle arrest, apoptosis, autophagy, and senescence through modulation of various signaling pathways, and may be effective in the management of cancers. Expand
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