Cancer chemopreventive activity of terpenoid coumarins from Ferula species.

  title={Cancer chemopreventive activity of terpenoid coumarins from Ferula species.},
  author={Mehrdad Iranshahi and Farhad Kalategi and Ramin Rezaee and Ahmad Reza Shahverdi and Chihiro Ito and Hiroshi Furukawa and Harukuni Tokuda and Masataka Itoigawa},
  journal={Planta medica},
  volume={74 2},
Several natural products have been found to have anti-tumor promoting activity. In the present study, we carried out a primary screening of ten terpenoid coumarins isolated from plants of the Ferula species, examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. Auraptene (7-geranyloxycoumarin, 1) and umbelliprenin (7-farnesyloxycoumarin, 2) were found to significantly inhibit EBV… CONTINUE READING
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