Cancer chemopreventive activity of maslinic acid: suppression of COX-2 expression and inhibition of NF-κB and AP-1 activation in Raji cells.

@article{Hsum2011CancerCA,
  title={Cancer chemopreventive activity of maslinic acid: suppression of COX-2 expression and inhibition of NF-κB and AP-1 activation in Raji cells.},
  author={Yap Wei Hsum and Wong Teck Yew and Paul Hong and Khoo Kong Soo and Lim Saw Hoon and Yeo Chew Chieng and Lim Yang Mooi},
  journal={Planta medica},
  year={2011},
  volume={77 2},
  pages={
          152-7
        }
}
Chronic inflammation is one of the predisposing factors for neoplastic transformation. Targeting inflammation through suppression of the pro-inflammatory pathway by dietary phytochemicals provides an important strategy for cancer prevention. Maslinic acid is a novel natural triterpenoid known to inhibit proliferation and induce apoptosis in some tumor cell lines. Although maslinic acid has cytotoxic and pro-apoptotic effects on cancer cells, the underlying mechanisms of its effects on the… CONTINUE READING

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