Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models

@article{Zhang2004CancerCA,
  title={Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models},
  author={Z. Zhang and Y. Wang and R. Yao and J. Li and Y. Yan and M. Regina and William L Lemon and C. Grubbs and R. Lubet and M. You},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={3841-3850}
}
  • Z. Zhang, Y. Wang, +7 authors M. You
  • Published 2004
  • Biology, Medicine
  • Oncogene
  • Antitumor B (ATB), also known as Zeng Sheng Ping, is a Chinese herbal mixture composed of six plants. Previously, clinical studies have shown a significant chemopreventive efficacy of ATB against human esophageal and lung cancers. In the present study, A/J mice harboring a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf and treated with benzo[a]pyrene were used to investigate the chemopreventive effects of ATB on chemically induced lung tumorigenesis. Mice with various genotypes… CONTINUE READING
    54 Citations

    Paper Mentions

    Observational Clinical Trial
    The purpose of this study is to evaluate the single-dose oral pharmacokinetics of an herbal supplement - Antitumor B - in healthy subjects.  
    ConditionsHealthy Adults
    InterventionDietary Supplement
    Chemoprevention of Lung Squamous Cell Carcinoma in Mice by a Mixture of Chinese Herbs
    • 36
    • PDF
    Prevention of lung cancer progression by bexarotene in mouse models
    • 36
    • PDF
    Chemopreventive Effects of Pioglitazone on Chemically Induced Lung Carcinogenesis in Mice
    • 39
    • PDF

    References

    SHOWING 1-10 OF 25 REFERENCES
    Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf
    • 36
    • PDF
    Inhibition of lung tumorigenesis by NSAIDS: a working hypothesis.
    • 74
    • Highly Influential
    Preclinical and clinical models of lung cancer chemoprevention.
    • 54
    A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression
    • 22
    • PDF
    Effect of Β-Sitosterol, a Plant Sterol, on Growth, Protein Phosphatase 2A, and Phospholipase D in LNCaP Cells
    • 53
    Phytosterols as anticancer dietary components: evidence and mechanism of action.
    • 522
    • Highly Influential
    • PDF
    Regulation of Apoptosis by α-Subunits of G12 and G13 Proteins via Apoptosis Signal-regulating Kinase-1*
    • 64
    • PDF
    Gα12 and Gα13 Regulate Extracellular Signal-regulated Kinase and c-Jun Kinase Pathways by Different Mechanisms in COS-7 Cells*
    • 103
    • PDF