Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models

  title={Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models},
  author={Z. Zhang and Y. Wang and R. Yao and J. Li and Y. Yan and M. Regina and William L Lemon and C. Grubbs and R. Lubet and M. You},
  • Z. Zhang, Y. Wang, +7 authors M. You
  • Published 2004
  • Biology, Medicine
  • Oncogene
  • Antitumor B (ATB), also known as Zeng Sheng Ping, is a Chinese herbal mixture composed of six plants. Previously, clinical studies have shown a significant chemopreventive efficacy of ATB against human esophageal and lung cancers. In the present study, A/J mice harboring a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf and treated with benzo[a]pyrene were used to investigate the chemopreventive effects of ATB on chemically induced lung tumorigenesis. Mice with various genotypes… CONTINUE READING
    54 Citations

    Paper Mentions

    Observational Clinical Trial
    The purpose of this study is to evaluate the single-dose oral pharmacokinetics of an herbal supplement - Antitumor B - in healthy subjects.  
    ConditionsHealthy Adults
    InterventionDietary Supplement
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