Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models

@article{Zhang2004CancerCA,
  title={Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models},
  author={Zhongqiu Zhang and Yian Wang and Ruisheng Yao and Jie Li and Ying Yan and Marie La Regina and William L Lemon and Clinton J. Grubbs and Ronald A. Lubet and Ming You},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={3841-3850}
}
Antitumor B (ATB), also known as Zeng Sheng Ping, is a Chinese herbal mixture composed of six plants. Previously, clinical studies have shown a significant chemopreventive efficacy of ATB against human esophageal and lung cancers. In the present study, A/J mice harboring a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf and treated with benzo[a]pyrene were used to investigate the chemopreventive effects of ATB on chemically induced lung tumorigenesis. Mice with various genotypes… CONTINUE READING
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