Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice.

@article{Schubert2004CancerCB,
  title={Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice.},
  author={Ralf Schubert and Laura Erker and Carrolee Barlow and Hiroyuki Yakushiji and Denise Larson and Angelo Russo and James B. Mitchell and Anthony Wynshaw-Boris},
  journal={Human molecular genetics},
  year={2004},
  volume={13 16},
  pages={1793-802}
}
Reactive oxygen species (ROS) are important endogenous etiological agents for DNA damage, and ROS perform critical signaling functions in apoptosis, stress responses and proliferation. The correlation between a lower incidence of cancer in people who consume a diet high in naturally occurring antioxidants and the observed increased ROS in cancerous tissues suggest that antioxidants may be used in cancer chemoprevention. We tested this hypothesis by determining whether the well-described… CONTINUE READING

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Tempol treatment reduced ROS , restored mitochondrial membrane potential , reduced tissue oxidative damage and oxidative stress , consistent with antioxidant effects .
Tempol treatment reduced ROS , restored mitochondrial membrane potential , reduced tissue oxidative damage and oxidative stress , consistent with antioxidant effects .
Thus , tempol acts as a novel chemopreventative agent in this mouse model of a human cancer prone syndrome , associated with broad antioxidant effects .
Tempol treatment reduced ROS , restored mitochondrial membrane potential , reduced tissue oxidative damage and oxidative stress , consistent with antioxidant effects .
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