Cancer cells exhibit clonal diversity in phenotypic plasticity

  title={Cancer cells exhibit clonal diversity in phenotypic plasticity},
  author={Robert Austin Mathis and Ethan S. Sokol and Piyush B. Gupta},
  booktitle={Open biology},
Phenotypic heterogeneity in cancers is associated with invasive progression and drug resistance. This heterogeneity arises in part from the ability of cancer cells to switch between phenotypic states, but the dynamics of this cellular plasticity remain poorly understood. Here we apply DNA barcodes to quantify and track phenotypic plasticity across hundreds of clones in a population of cancer cells exhibiting epithelial or mesenchymal differentiation phenotypes. We find that the epithelial-to… CONTINUE READING
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