Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

@article{Gascoigne2008CancerCD,
  title={Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.},
  author={Karen E. Gascoigne and Stephen S Taylor},
  journal={Cancer cell},
  year={2008},
  volume={14 2},
  pages={111-22}
}
Drugs targeting the mitotic spindle are used extensively during chemotherapy, but surprisingly, little is known about how they kill tumor cells. This is largely because many of the population-based approaches are indirect and lead to vague and confusing interpretations. Here, we use a high-throughput automated time-lapse light microscopy approach to systematically analyze over 10,000 single cells from 15 cell lines in response to three different classes of antimitotic drug. We show that the… CONTINUE READING
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