Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma.

@article{Jube2012CancerCS,
  title={Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma.},
  author={Sandro L R Jube and Zeyana S. Rivera and Marco Emilio Bianchi and Amy C. Powers and Ena Wang and I Pagano and Harvey I. Pass and Giovanni Gaudino and Michele Carbone and Haining Yang},
  journal={Cancer research},
  year={2012},
  volume={72 13},
  pages={
          3290-301
        }
}
Human malignant mesothelioma is an aggressive and highly lethal cancer that is believed to be caused by chronic exposure to asbestos and erionite. Prognosis for this cancer is generally poor because of late-stage diagnosis and resistance to current conventional therapies. The damage-associated molecular pattern protein HMGB1 has been implicated previously in transformation of mesothelial cells. Here we show that HMGB1 establishes an autocrine circuit in malignant mesothelioma cells that… CONTINUE READING

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