Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma.

  title={Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma.},
  author={Sandro L R Jube and Zeyana S. Rivera and Marco Emilio Bianchi and Amy C. Powers and Ena Wang and I Pagano and Harvey I. Pass and Giovanni Gaudino and Michele Carbone and Haining Yang},
  journal={Cancer research},
  volume={72 13},
Human malignant mesothelioma is an aggressive and highly lethal cancer that is believed to be caused by chronic exposure to asbestos and erionite. Prognosis for this cancer is generally poor because of late-stage diagnosis and resistance to current conventional therapies. The damage-associated molecular pattern protein HMGB1 has been implicated previously in transformation of mesothelial cells. Here we show that HMGB1 establishes an autocrine circuit in malignant mesothelioma cells that… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 86 extracted citations

Regulation of Tumor Progression by Programmed Necrosis

Oxidative medicine and cellular longevity • 2018
View 5 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 42 references

Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature

JR van Beijnum, RP Dings, +3 authors KH Mayo
Blood. 2006;108:2339-48. Research. on November • 2012
View 1 Excerpt

Malignant mesothelioma: facts, myths, and hypotheses.

Journal of cellular physiology • 2012
View 3 Excerpts

Molecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2012
View 2 Excerpts

Benign and Malignant Mesothelioma

HI Pass, N Vogelzang, SM Hahn, M. Carbone
editor. Cancer, Principles • 2011
View 2 Excerpts

Erionite exposure in North Dakota and Turkish villages with mesothelioma.

Proceedings of the National Academy of Sciences of the United States of America • 2011
View 4 Excerpts

Similar Papers

Loading similar papers…