Cancer cell-secreted proteomes as a basis for searching potential tumor markers: nasopharyngeal carcinoma as a model.

@article{Wu2005CancerCP,
  title={Cancer cell-secreted proteomes as a basis for searching potential tumor markers: nasopharyngeal carcinoma as a model.},
  author={Chih-Ching Wu and Kun-Yi Chien and N N Tsang and K. -P. Chang and Sheng-po Hao and Chuang-Hui Tsao and Yu-sun Chang and J S Yu},
  journal={Proteomics},
  year={2005},
  volume={5 12},
  pages={3173-82}
}
Nasopharyngeal carcinoma (NPC) is commonly diagnosed late due to its deep location and vague symptoms. To identify biomarkers for early NPC diagnosis, secreted proteomes of two NPC cell lines were analyzed. Proteins in the NPC cell-line cultured media were systematically identified by SDS-PAGE combined with MALDI-TOF MS. Twenty-three proteins were found in cultured media from both NPC cell lines. Among them, fibronectin, Mac-2 binding protein (Mac-2 BP), and plasminogen activator inhibitor 1… CONTINUE READING

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