Cancer cell-derived lymphotoxin mediates reciprocal tumour-stromal interactions in human ovarian cancer by inducing CXCL11 in fibroblasts.

@article{Lau2014CancerCL,
  title={Cancer cell-derived lymphotoxin mediates reciprocal tumour-stromal interactions in human ovarian cancer by inducing CXCL11 in fibroblasts.},
  author={T K Lau and Tony Kwok-Hung Chung and Tak Hong Cheung and Loucia Kit-Ying Chan and Leonard Wing-Hong Cheung and So-fan Yim and Nelson Siu and K. D. Lo and May Mei-Yung Yu and Hagen Kulbe and Frances R. Balkwill and Joseph Kwong},
  journal={The Journal of pathology},
  year={2014},
  volume={232 1},
  pages={43-56}
}
We have investigated the role of cytokine lymphotoxin in tumour-stromal interactions in human ovarian cancer. We found that lymphotoxin overexpression is commonly shared by the cancer cells of various ovarian cancer subtypes, and lymphotoxin-beta receptor (LTBR) is expressed ubiquitously in both the cancer cells and cancer-associated fibroblasts (CAFs). In monoculture, we showed that ovarian cancer cells are not the major lymphotoxin-responsive cells. On the other hand, our co-culture studies… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 44 references

Inhibition of the lymphotoxin pathway as a therapy for autoimmune disease.

Immunological reviews • 2008
View 4 Excerpts
Highly Influenced

The unexpected role of lymphotoxin beta receptor signaling in carcinogenesis: from Copyright  2013 Pathological Society of Great Britain and Ireland

MJ Wolf, GM Seleznik, N Zeller
J Pathol • 2014

Pathway-based personalized analysis of cancer.

Proceedings of the National Academy of Sciences of the United States of America • 2013

Discovery of potent and specific CXCR3 antagonists.

Bioorganic & medicinal chemistry letters • 2012
View 1 Excerpt

The chemokine system and cancer.

The Journal of pathology • 2012
View 1 Excerpt

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