Cancer cell death by programmed necrosis?

  title={Cancer cell death by programmed necrosis?},
  author={Piet Borst and Sven Rottenberg},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  volume={7 6},
A recent paper by Zong et al. describes how alkylating agents kill cells by a process they term "programmed necrosis," induced by excessive activation of PARP resulting in degradation of cytosolic NAD(+) and inhibition of glycolysis. We argue that it is not obvious whether chemotherapy in patients can induce sufficient NAD(+) loss to affect glycolysis; that the "programmed" nature of the necrosis requires more evidence; and that there are mechanisms making cancer cells hypersensitive to DNA… CONTINUE READING