Cancer-causing human papillomavirus E6 proteins display major differences in the phospho-regulation of their PDZ interactions.

@article{Boon2015CancercausingHP,
  title={Cancer-causing human papillomavirus E6 proteins display major differences in the phospho-regulation of their PDZ interactions.},
  author={Siaw Shi Boon and Vjekoslav Tomai{\'c} and Miranda Thomas and Sally Roberts and Lawrence Banks},
  journal={Journal of virology},
  year={2015},
  volume={89 3},
  pages={
          1579-86
        }
}
UNLABELLED Previous studies have shown that the cancer-causing high-risk human papillomavirus (HPV) E6 oncoproteins have PDZ binding potential, an activity which is important for their ability to support the viral life cycle and to cooperate in the induction of malignancy. However, PDZ interactions are not constitutive, and they can be negatively regulated by phosphorylation within the E6 PDZ binding motif (PBM). In this study, we have investigated the differential regulation of the HPV E6 PBMs… CONTINUE READING

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