Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue.

@article{Figueras2005CancerCR,
  title={Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue.},
  author={Maite Figueras and S{\'i}lvia Busquets and Neus Carb{\'o} and Vanessa Almendro and Josep Maria Argil{\'e}s and Francisco Javier L{\'o}pez-Soriano},
  journal={International journal of oncology},
  year={2005},
  volume={27 3},
  pages={855-60}
}
The mRNA content of both TNF-alpha and its receptors (TNFR1 and TNFR2) in skeletal muscle and adipose tissue from cachectic rats has been assessed. The implantation of the Yoshida AH-130 ascites hepatoma resulted in substantial decrease in skeletal muscle TNF-alpha expression as early as at day 2 following tumour implantation. However, the mRNA content for the two receptors followed a different pattern, being significantly increased at day 7. In adipose tissue the expression of the TNF-alpha… CONTINUE READING