Cancer cachexia is regulated by selective targeting of skeletal muscle gene products.

@article{Acharyya2004CancerCI,
  title={Cancer cachexia is regulated by selective targeting of skeletal muscle gene products.},
  author={Swarnali Acharyya and Katherine J. Ladner and Lori L Nelsen and Jeffrey S. Damrauer and Peter J Reiser and Steven J Swoap and Denis C. Guttridge},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={114 3},
  pages={
          370-8
        }
}
Cachexia is a syndrome characterized by wasting of skeletal muscle and contributes to nearly one-third of all cancer deaths. Cytokines and tumor factors mediate wasting by suppressing muscle gene products, but exactly which products are targeted by these cachectic factors is not well understood. Because of their functional relevance to muscle architecture, such targets are presumed to represent myofibrillar proteins, but whether these proteins are regulated in a general or a selective manner is… CONTINUE READING

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