Cancer cachexia: Diagnosis, assessment, and treatment.

@article{Sadeghi2018CancerCD,
  title={Cancer cachexia: Diagnosis, assessment, and treatment.},
  author={Mohammad Bagher Sadeghi and Mahsa Keshavarz-Fathi and Vickie E. Baracos and Jann Arends and Maryam Mahmoudi and Nima Rezaei},
  journal={Critical reviews in oncology/hematology},
  year={2018},
  volume={127},
  pages={
          91-104
        }
}
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Revisiting Cancer Cachexia: Pathogenesis, Diagnosis, and Current Treatment Approaches
  • M. Baba, S. Buch
  • Medicine, Biology
    Asia-Pacific journal of oncology nursing
  • 2021
TLDR
There is a need to develop a multimodal treatment approach combining pharmacology, exercise program, and nutritional support to target anorexia and the severe metabolic changes encountered in cancer cachexia.
Management of Cancer Cachexia: Attempting to Develop New Pharmacological Agents for New Effective Therapeutic Options
TLDR
The recent knowledge regarding cachexia mediators and pathways involved in skeletal muscle (SM) and adipose tissue (AT) loss are outlined, mainly from the experimental cachexia standpoint, then retracing the unimodal treatment options that have been developed to the present day.
Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia
TLDR
There are no studies evaluating therapeutic options in the clinical setting regarding cancer-induced cardiac cachexia, and further prospective studies specifically focusing on the assessment and treatment of the cardiac component of cachexia are needed.
Contemporary Insights into Cancer Cachexia for Oncology Nurses
  • D. Boyle
  • Medicine
    Asia-Pacific journal of oncology nursing
  • 2021
TLDR
Heightened education about the pathophysiology of cancer cachexia and awareness of intra-familial emotional distress can enhance oncology nurses' advocacy about, and attentiveness to, this common manifestation of advanced cancer.
Cancer-Mediated Muscle Cachexia: Etiology and Clinical Management
A multimodal approach to cancer-related cachexia: from theory to practice
TLDR
The multifaceted features of this syndrome support the rationale for personalized therapy, and a multimodal approach is likely to offer the best option to address key cachexia-related issues.
Diet-related interventions for cancer-associated cachexia
TLDR
Whether different forms of multimodal therapy—combinations of cancer treatment, dietary regimens, anti-inflammatory therapy, and physical therapy—are effective methods to improve outcomes in advanced cancer patients with cachexia is examined.
Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia
TLDR
Understanding the interplay and the differences between these conditions is critical to advance basic and translational research in this field, improving the accuracy of diagnosis and contributing to finally achieve effective therapies for affected patients.
Assessment of Cancer-Associated Cachexia — How to Approach Physical Function Evaluation
TLDR
A tiered approach to cachexia-related functional assessment is recommended that involves evaluation of activities of daily living, general mobility, and exercise tolerance in a prioritized sequence to efficiently and broadly evaluate the diverse functional needs of cachexia patients.
Role for Plant-Derived Antioxidants in Attenuating Cancer Cachexia
TLDR
Antioxidants have therapeutic potential to attenuate cancer-related muscle loss, with polyphenols, a group of plant-derived antioxidants, being the most widely investigated.
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References

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Drug treatments should ideally be combined with exercise training to maximize efficacy and ultimately reduce mortality and enhance the quality of life of patients with cancer cachexia.
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The successful management of pancreatic cancer cachexia will likely require a multimodal approach that includes nutritional support and combination pharmaceutical interventions, as well as current and future treatments.
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By targeting downstream effectors that are common in these pathways, it is believed that a better therapeutic approach to reverse muscle wasting and maintain muscle function during cancer cachexia will be achieved.
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