Cancer biology: Another string to the bow

  title={Cancer biology: Another string to the bow},
  author={Gemma K. Alderton},
  journal={Nature Reviews Molecular Cell Biology},
the homologous recombination (HR) DNA-repair pathway, such as BRCA2 and the RecQ helicases WRN and BLM, are often associated with cancer owing to unproductive HR repair and genomic instability. Reporting in Cell, Simon Boulton and colleagues have identified a new HR gene in humans that may also be deregulated in cancer. In Saccharomyces cerevisiae, the helicase Srs2 antagonizes the initial steps of HR, and srs2 mutants exhibit spontaneous recombination and sensitivity to DNA-damaging agents… CONTINUE READING