Cancer-associated mutations in chromatin remodeler hSNF5 promote chromosomal instability by compromising the mitotic checkpoint.

@article{Vries2005CancerassociatedMI,
  title={Cancer-associated mutations in chromatin remodeler hSNF5 promote chromosomal instability by compromising the mitotic checkpoint.},
  author={Robert G. J. Vries and Vladimir Bezrookove and Lobke M P Zuijderduijn and Sima Kheradmand Kia and Ada Houweling and Igor Oruetxebarria and Anton K. Raap and C. Peter Verrijzer},
  journal={Genes & development},
  year={2005},
  volume={19 6},
  pages={665-70}
}
The hSNF5 subunit of human SWI/SNF ATP-dependent chromatin remodeling complexes is a tumor suppressor that is inactivated in malignant rhabdoid tumors (MRTs). Here, we report that loss of hSNF5 function in MRT-derived cells leads to polyploidization and chromosomal instability. Re-expression of hSNF5 restored the coupling between cell cycle progression and ploidy checkpoints. In contrast, cancer-associated hSNF5 mutants harboring specific single amino acid substitutions exacerbated poly- and… CONTINUE READING
52 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

Similar Papers

Loading similar papers…