Cancer-associated fibroblasts provide a suitable microenvironment for tumor development and progression in oral tongue squamous cancer

@inproceedings{Li2015CancerassociatedFP,
  title={Cancer-associated fibroblasts provide a suitable microenvironment for tumor development and progression in oral tongue squamous cancer},
  author={Huan Li and Ji Zhang and Shu-wei Chen and Lu-lu Liu and Lei Li and Fan Gao and Shi-Min Zhuang and Liping Wang and Yan Li and Ming Hua Song},
  booktitle={Journal of Translational Medicine},
  year={2015}
}
Oral tongue squamous cell carcinoma (OTSCC) is still associated with a poor prognosis due to local recurrence and metastasis. Cancer-associated fibroblasts (CAFs) play an important role in the complex processes of cancer stroma interaction and tumorigenesis. This study aims to determine the role of CAFs in the development and progression of OTSCC. Immunohistochemistry was performed to evaluate the frequency and distribution of CAFs in 178 paraffin specimens from patients with OTSCC… CONTINUE READING
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Prognostic value of the immunohistochemical detection of cancer-associated fibroblasts in oral cancer: A systematic review and meta-analysis.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology • 2018
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