Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages

@article{Takahashi2017CancerassociatedFP,
  title={Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages},
  author={Hideyuki Takahashi and K. Sakakura and T. Kudo and M. Toyoda and K. Kaira and T. Oyama and K. Chikamatsu},
  journal={Oncotarget},
  year={2017},
  volume={8},
  pages={8633 - 8647}
}
Stromal cells in the tumor microenvironment (TME) closely interact with tumor cells and affect tumor cell behavior in diverse manners. We herein investigated the mechanisms by which cancer-associated fibroblasts (CAFs) affect the functional polarization of tumor-associated macrophages (TAMs) in oral squamous cell carcinoma (OSCC) in vitro and in human cancer samples. The expression of CD68, CD14, CD163, CD200R, CD206, HLA-G, CD80, and CD86 was higher in CD14-positive cells co-cultured with the… Expand
Oral Squamous Cell Carcinoma Contributes to Differentiation of Monocyte-Derived Tumor-Associated Macrophages via PAI-1 and IL-8 Production
  • Kazuki Kai, M. Moriyama, +8 authors Seiji Nakamura
  • Medicine
  • International journal of molecular sciences
  • 2021
Tumor-associated macrophages (TAMs) promote cancer cell proliferation and metastasis, as well as anti-tumor immune suppression. Recent studies have shown that tumors enhance the recruitment andExpand
The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment
TLDR
Recent advancements in understanding of how CAFs drive the recruitment and functional fate of tumor-infiltrating immune cells toward an immunosuppressive microenvironment are focused on, and outlook on future therapeutic implications are provided. Expand
Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer
TLDR
The cross talk between MSCs and TAMs could contribute to cancer biology by inducing the EMT process, metastasis, immune invasion, and immunotherapy resistance in cancer cells, but molecular mechanisms underlying interactions in gastric cancer progression need to be thoroughly elucidated. Expand
Fibroblast activation protein-positive fibroblasts promote tumor progression through secretion of CCL2 and interleukin-6 in esophageal squamous cell carcinoma
TLDR
It is shown that fibroblast activation protein (FAP) induces the tumor promoting phenotype of fibroblasts through secretion of several cytokines, and may be a valuable prognostic marker and specific target of anti-cancer therapy. Expand
Fibroblast-Mediated Immunoregulation of Macrophage Function Is Maintained after Irradiation
TLDR
It is shown that CAFs promote changes in M0-macrophages that harmonize with both M1-and M2-phenotypes and down-regulate pro-inflammatory features of M 1-polarized macrophages, and Notably, ionizing radiation does not curtail the CAF-mediated immunosuppressive effects. Expand
Fibroblast heterogeneity in tumor micro-environment: Role in immunosuppression and new therapies.
TLDR
The main current knowledge on CAFs heterogeneity and immunosuppressive microenvironment, as well as their potential therapeutic implications are described. Expand
Extracellular vesicles derived from cancer-associated fibroblasts induce the migration and invasion of oral squamous cell carcinoma
TLDR
A significant role of CAF-EV is suggested in promoting the migration and invasion of OSCC cells, which are related to the activation of cancer-related pathways. Expand
Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts
TLDR
The current understanding of how activated tumor-associated fibroblasts accomplish this task as well as their potential therapeutic implications are described. Expand
Cancer-associated fibroblasts as key regulators of the breast cancer tumor microenvironment
TLDR
The impact of CAFs on breast cancer biology is discussed and their heterogeneity, origin and their role in tumor progression, ECM remodeling, therapy resistance, metastasis, and the challenges ahead of targeting CAFs to improve therapy response are highlighted. Expand
Cancer-Associated Fibroblasts in Oral Cancer: A Current Perspective on Function and Potential for Therapeutic Targeting
The role of the tumour microenvironement (TME) in cancer progression and resistance to therapies is now widely recognized. The most prominent non-immune cell type in the microenvironment of oralExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 43 REFERENCES
Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma
TLDR
It is demonstrated that CAFs collaborated with tumor cells in the TME to establish an immunosuppressive network that facilitated tumor evasion from immunological destruction. Expand
Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity
TLDR
The inhibitory effect of tumor-derived fibroblasts was far stronger and directly correlated with their ability to produce PGE2 either constitutively or upon induction by NK cells, which resulted in an impairment of the NK cell-mediated killing of melanoma target cells. Expand
Tumor‐stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7
TLDR
The reciprocal relationship of the molecular crosstalk regulating the invasion of oral squamous cell carcinoma (OSCC) is confirmed and new potential targets for future therapy are described. Expand
Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors
TLDR
A novel role for macrophages in EMT-promoted tumor progression is identified and a positive correlation between intratumoral macrophage densities, EMT markers, intraepithelial TGF-β levels and tumor grade is identified. Expand
Tumor-produced, active Interleukin-1 β regulates gene expression in carcinoma-associated fibroblasts
TLDR
A constitutive high interleukin-1β (IL1-β) expression in SCC-25 cells in normal and in co-cultured conditions is found, which leads to IL1- β-stimulated gene expression changes in tumor-associated fibroblasts, which are involved in tumor progression. Expand
The role of myofibroblasts in upregulation of S100A8 and S100A9 and the differentiation of myeloid cells in the colorectal cancer microenvironment.
TLDR
The upregulation of S100A8/A9 in tumor-infiltrated myeloid cells could be triggered by IL-6 and IL-8 released from myofibroblasts, and the differentiation of myeloids into MDSCs or M2 macrophages in the CRC microenvironment might be induced. Expand
IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion.
TLDR
It is demonstrated that high levels of cathepsin protease activity are induced in the majority of macrophages in the microenvironment of pancreatic islet cancers, mammary tumors, and lung metastases during malignant progression and that interleukin-4 (IL-4) is responsible for inducing cat hepsin activity in macrophage in vitro and in vivo. Expand
Cancer-associated fibroblasts and CD163-positive macrophages in oral squamous cell carcinoma: their clinicopathological and prognostic significance.
  • N. Fujii, K. Shomori, +4 authors Hisao Ito
  • Biology, Medicine
  • Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • 2012
TLDR
Cancer-associated fibroblasts and CD163-positive macrophages may be potential prognostic predictors of oral squamous cell carcinoma, focusing on clinicopathological factors and patient prognosis as well as cancer invasion. Expand
Regulation of HGF and SDF-1 expression by oral fibroblasts--implications for invasion of oral cancer.
TLDR
Fibroblast-derived HGF and SDF-1 appear to play central roles in the reciprocal interactions between OSCC cells and underlying stromal fibroblasts leading to the local invasion of oral cancer. Expand
Response to Comment on “Characterization of Human Lung Tumor-Associated Fibroblasts and Their Ability to Modulate the Activation of Tumor-Associated T Cells”
TLDR
TAF in human NSCLC are functionally and phenotypically heterogeneous and provide multiple complex regulatory signals that have the potential to enhance or suppress TAT function in the tumor microenvironment. Expand
...
1
2
3
4
5
...