Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma

@article{Cheng2018CancerassociatedFI,
  title={Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma},
  author={Yusheng Cheng and H. Li and Yi-nan Deng and Y. Tai and Kaining Zeng and Ying-cai Zhang and Wei Liu and Q. Zhang and Y. Yang},
  journal={Cell Death \& Disease},
  year={2018},
  volume={9}
}
Emerging evidence indicate that cancer-associated fibroblasts (CAFs) affect tumor progression by reshaping the tumor microenvironment. Neutrophils are prominent components of solid tumors and important in cancer progression. Whether the phenotype and function of neutrophils in hepatocellular carcinoma (HCC) are influenced by CAFs is not well understood. Herein, we investigated the effect of HCC-derived CAFs (HCC-CAFs) on the neutrophils and explored the biological role of this effect. We found… Expand
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Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma
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