Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness.

@article{Giannoni2011CancerAF,
  title={Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness.},
  author={Elisa Giannoni and Francesca Bianchini and Lido Calorini and Paola Chiarugi},
  journal={Antioxidants & redox signaling},
  year={2011},
  volume={14 12},
  pages={2361-71}
}
Cancer-associated fibroblasts (CAFs) are key determinants in the malignant progression of cancer, supporting tumorigenesis and metastasis. CAFs also mediate epithelial mesenchymal transition (EMT) of tumor cells and their achievement of stem cell traits. We demonstrate that CAFs induce EMT and stemness through a proinflammatory signature, which exploits… CONTINUE READING