Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer

@inproceedings{Zhang2019CancerassociatedFE,
  title={Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer},
  author={Rongsheng Zhang and Fan Qi and Fei Zhao and Geng Li and Shengli Shao and Xiaochao Zhang and Lifei Yuan and Yongdong Feng},
  booktitle={Cell Death & Disease},
  year={2019}
}
Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) are important components of the tumor microenvironment, which have been reported to localize in colorectal carcinomas where they promote tumor progression. One of the crucial effects they exerted is immune-suppression, which was reported recently, however, the overall mechanism has not been fully addressed. In this study, it was shown that TAMs were enriched in colorectal cancer, and their infiltration was associated… CONTINUE READING
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