Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue.

@article{Karagiannis2012CancerassociatedFD,
  title={Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue.},
  author={George S Karagiannis and T Poutahidis and Susan E. Erdman and Richard Kirsch and Robert H. Riddell and Eleftherios P Diamandis},
  journal={Molecular cancer research : MCR},
  year={2012},
  volume={10 11},
  pages={1403-18}
}
Neoplastic cells recruit fibroblasts through various growth factors and cytokines. These "cancer-associated fibroblasts" (CAF) actively interact with neoplastic cells and form a myofibroblastic microenvironment that promotes cancer growth and survival and supports malignancy. Several products of their paracrine signaling repertoire have been recognized as tumor growth and metastasis regulators. However, tumor-promoting cell signaling is not the only reason that makes CAFs key components of the… CONTINUE READING
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Antibody neutralization of vascular endothelial Interdigital Model of Metastasis www.aacrjournals.org Mol Cancer Res

  • TR Howdieshell, D Callaway, WL Webb, MD Gaines, CD JrProcter, Sathyanarayana
  • November 2012 1415 on November
  • 2012
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