Cancer-associated fibroblast-derived Lumican promotes gastric cancer progression via the integrin β1-FAK signaling pathway.

@article{Wang2017CancerassociatedFL,
  title={Cancer-associated fibroblast-derived Lumican promotes gastric cancer progression via the integrin β1-FAK signaling pathway.},
  author={Xiaofeng Wang and Quan Zhou and Zhenjia Yu and Xiongyan Wu and Xuehua Chen and Jianfang Li and Chen Li and Min Yan and Zheng Gang Zhu and Bing-Ya Liu and Liping Su},
  journal={International journal of cancer},
  year={2017},
  volume={141 5},
  pages={998-1010}
}
Gastric cancer (GC) is one of the most frequent malignant tumors worldwide and is associated with high invasiveness, high metastasis and poor prognosis. Cancer-associated fibroblasts (CAFs), residing around tumor cells in tumor stroma, are important modifiers of tumor initiation and progression. However, the molecular mechanisms by which CAF's modulate tumor development have yet not to be characterized in GC. Here we performed tissue assay analyses identifying that Lumican, an extracellular… CONTINUE READING
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