Cancer-associated alteration in fatty acid binding to albumin studied by spin-label electron spin resonance.

@article{Gurachevsky2007CancerassociatedAI,
  title={Cancer-associated alteration in fatty acid binding to albumin studied by spin-label electron spin resonance.},
  author={Andrey Gurachevsky and Ekaterina Muravskaya and Tatjana Gurachevskaya and Lena Smirnova and Vladimir Muravsky},
  journal={Cancer investigation},
  year={2007},
  volume={25 6},
  pages={
          378-83
        }
}
Human serum albumin accumulates low molecular weight biomarkers related to cancer. This accumulation can lead to allosteric modification of albumin and change its ability to bind essential fatty acids. Using 16-doxyl-stearic acid spin probe, which is specific for albumin, the serum samples of 98 patients with a variety of cancer types and 86 cancer free individuals were analysed by electron spin resonance (ESR) spectroscopy in order to evaluate cancer-induced modifications that occur to albumin… CONTINUE READING