Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2

@article{Agrawal1998CancerassociatedMM,
  title={Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2},
  author={Babita Agrawal and Mark J. Krantz and Mark A. Reddish and Bryan Michael Longenecker},
  journal={Nature Medicine},
  year={1998},
  volume={4},
  pages={43-49}
}
A number of adenocarcinomas abundantly express and secrete underglycosylated MUC1 mucin. Underglycosylation exposes tandem repeat peptide sequences on cancer-associated MUC1 mucin that are normally cryptic. High levels of MUC1 mucin are correlated with a poor prognosis and immunosuppression in adenocarcinoma patients. In this report we show that cancer-associated MUC1 mucin, affinity-purified from ascites fluids of cancer patients, and synthetic tandem repeats of MUC1 mucin core peptide can… CONTINUE READING
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