Cancer as a channelopathy: ion channels and pumps in tumor development and progression

@inproceedings{Litan2015CancerAA,
  title={Cancer as a channelopathy: ion channels and pumps in tumor development and progression},
  author={Alisa Litan and Sigrid A. Langhans},
  booktitle={Front. Cell. Neurosci.},
  year={2015}
}
Increasing evidence suggests that ion channels and pumps not only regulate membrane potential, ion homeostasis, and electric signaling in excitable cells but also play important roles in cell proliferation, migration, apoptosis and differentiation. Consistent with a role in cell signaling, channel proteins and ion pumps can form macromolecular complexes with growth factors, and cell adhesion and other signaling molecules. And while cancer is still not being cataloged as a channelopathy, as the… CONTINUE READING
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