Cancer as a Complex Phenotype: Pattern of Cancer Distribution within and beyond the Nuclear Family

@article{Amundadottir2004CancerAA,
  title={Cancer as a Complex Phenotype: Pattern of Cancer Distribution within and beyond the Nuclear Family},
  author={Laufey Thora Amundadottir and Sverrir Thorvaldsson and Daniel Fannar Gudbjartsson and Patrick Sulem and Kristleifur Kristj{\'a}nsson and Sigurdur Arnason and Jeffrey Robert Gulcher and Johannes Bjornsson and Augustine Kong and Unnur Thorsteinsdottir and K{\'a}ri Stef{\'a}nsson},
  journal={PLoS Medicine},
  year={2004},
  volume={1},
  pages={1301 - 1308}
}
BACKGROUND The contribution of low-penetrant susceptibility variants to cancer is not clear. With the aim of searching for genetic factors that contribute to cancer at one or more sites in the body, we have analyzed familial aggregation of cancer in extended families based on all cancer cases diagnosed in Iceland over almost half a century. METHODS AND FINDINGS We have estimated risk ratios (RRs) of cancer for first- and up to fifth-degree relatives both within and between all types of… CONTINUE READING