Cancer antigens: immune recognition of self and altered self

  title={Cancer antigens: immune recognition of self and altered self },
  author={Alan N. Houghton},
  journal={The Journal of Experimental Medicine},
  pages={1 - 4}
A tacit assumption of cancer immunology has been that tumors express non-self or "foreign" antigens. The recent identification of a handful of potentially immunogenic cancer antigens shows that they are not truly foreign. Although the boundary between self and non-self is not well-defined, this first look at cancer antigens fits more with a self/altered self paradigm than with the non-self paradigm for antigens recognized in infectious diseases. 
Highly Cited
This paper has 382 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications citing this paper.
Showing 1-10 of 183 extracted citations

Biological and immunological aspects of malignant mesothelioma.

The European respiratory journal • 1995
View 3 Excerpts
Highly Influenced

A polymeric conjugate foreignizing tumor cells for targeted immunotherapy in vivo.

Journal of controlled release : official journal of the Controlled Release Society • 2015
View 1 Excerpt

383 Citations

Citations per Year
Semantic Scholar estimates that this publication has 383 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 25 references

A new gene coding for a differentiation antigen recognized by autologous cytologic T lymphocytes on HLA-A2 melanomas

P. G. Coulie, V. Brichard, +8 authors T. Boon
J. Exi~ Med • 1994
View 1 Excerpt

Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor

Y. Kawakami, S. Eliyanu, +5 authors S. A. Rosenberg
Proc. Natl. Acad. Sci. USA • 1994
View 1 Excerpt

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA3

Y. Kawakami, S. Eliyahu, +5 authors S. A. Rosenberg
Houghton on July 12, • 1994
View 1 Excerpt

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

Proceedings of the National Academy of Sciences of the United States of America • 1994
View 2 Excerpts

Melano - cyte lineage - specific antigen gpl 00 is recognized by melanoma - derived tumor - infiltrating lymphocytes

A. J. de Boer, Y. Kawakami, S. A. Rosenberg, G. J. Adema, C. G. Figdor
J . Exp . Med . • 1994

Melanocyte lineage-specific antigen gpl00 is recognized by melanomaderived tumor-infiltrating lymphocytes.J

A.B.H. Bakker, M.W.J. Schreurs, +4 authors C. G. Figdor
Exp. Med • 1994
View 2 Excerpts