Cancer and the Immune System: Basic Concepts and Targets for Intervention.

  title={Cancer and the Immune System: Basic Concepts and Targets for Intervention.},
  author={Drew Mark Pardoll},
  journal={Seminars in oncology},
  volume={42 4},
A number of consensuses regarding cancer immunology have recently emerged from both preclinical immunotherapy models and analysis of cancer patients. First and foremost, the natural state of endogenous tumor reactive T cells is characterized by general hyporesponsiveness or anergy. This is likely due to a number of mechanisms that tumors use to induce tolerance as they develop. While many of the newer generation vaccines can effectively transfer antigen to and activate dendritic cells, T-cell… CONTINUE READING
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