Cancer and Chemotherapy Contribute to Muscle Loss by Activating Common Signaling Pathways

@inproceedings{Barreto2016CancerAC,
  title={Cancer and Chemotherapy Contribute to Muscle Loss by Activating Common Signaling Pathways},
  author={Rafael Barreto and Giorgia Mandili and Frank A. Witzmann and Francesco Novelli and Teresa A. Zimmers and Andrea Bonetto},
  booktitle={Front. Physiol.},
  year={2016}
}
Cachexia represents one of the primary complications of colorectal cancer due to its effects on depletion of muscle and fat. Evidence suggests that chemotherapeutic regimens, such as Folfiri, contribute to cachexia-related symptoms. The purpose of the present study was to investigate the cachexia signature in different conditions associated with severe muscle wasting, namely Colon-26 (C26) and Folfiri-associated cachexia. Using a quantitative LC-MS/MS approach, we identified significant changes… CONTINUE READING