Cancer adaptations: Atavism, de novo selection, or something in between?

  title={Cancer adaptations: Atavism, de novo selection, or something in between?},
  author={Fr{\'e}d{\'e}ric Thomas and Beata Ujvari and François N.R. Renaud and Mark David Vincent},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={39 8}
From an evolutionary perspective, both atavism and somatic evolution/convergent evolution theories can account for the consistent occurrence, and astounding attributes of cancers: being able to evolve from a single cell to a complex organized system, and malignant transformations showing significant similarities across organs, individuals, and species. Here, we first provide an overview of these two hypotheses, including the possibility of them not being mutually exclusive, but rather… CONTINUE READING
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