Cancer Vulnerabilities Unveiled by Genomic Loss

  title={Cancer Vulnerabilities Unveiled by Genomic Loss},
  author={Deepak Nijhawan and Travis Ian Zack and Yin Ren and Matthew R. Strickland and Rebecca Lamothe and Steven E Schumacher and Aviad Tsherniak and Henrike C. Besche and Joseph Rosenbluh and Shyemaa Shehata and Glenn S Cowley and Barbara A. Weir and Alfred L Goldberg and Jill P. Mesirov and David E Root and Sangeeta N. Bhatia and Rameen Beroukhim and William C. Hahn},
Due to genome instability, most cancers exhibit loss of regions containing tumor suppressor genes and collateral loss of other genes. To identify cancer-specific vulnerabilities that are the result of copy number losses, we performed integrated analyses of genome-wide copy number and RNAi profiles and identified 56 genes for which gene suppression specifically inhibited the proliferation of cells harboring partial copy number loss of that gene. These CYCLOPS (copy number alterations yielding… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 28 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 69 extracted citations

Proteasome dysregulation in human cancer: implications for clinical therapies

Cancer and Metastasis Reviews • 2017
View 3 Excerpts
Highly Influenced

Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.

BioEssays : news and reviews in molecular, cellular and developmental biology • 2017
View 3 Excerpts
Highly Influenced

Genetics of Proteasome Diseases

Scientifica • 2013
View 3 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 35 references

DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes

Nucleic Acids Research • 2009
View 1 Excerpt
Highly Influenced

Recognition and processing of ubiquitin-protein conjugates by the proteasome.

Annual review of biochemistry • 2009
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…