Cancer Therapy : Preclinical The Nedd 8-Activating Enzyme Inhibitor MLN 4924 Thwarts Microenvironment-Driven NFk B Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells

Abstract

Background: Stromal-mediated signaling enhances NF-kB pathway activity in chronic lymphocytic leukemia (CLL) B cells, leading to cell survival and chemoresistance. Ubiquitination of IkBamay partially account for constitutive activation of NF-kB. MLN4924 is an investigational agent that inhibits the Nedd8activating enzyme, thereby neutralizing Cullin-RING… (More)

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