Cancer Therapy : Preclinical Preclinical Activity of theOral Proteasome InhibitorMLN 9708 in Myeloma Bone Disease

  title={Cancer Therapy : Preclinical Preclinical Activity of theOral Proteasome InhibitorMLN 9708 in Myeloma Bone Disease},
  author={AntonioGarcia-Gomez and Dalia Quwaider and MiriamCanavese and EnriqueM. Ocio and Ze Tian and Juan Francisco B. Blanco and Allison J. Berger and Carlos Ortiz-de-Solorzano and andez-Iglesias and Anton C. M. Martens and Richard W. J. Groen and Joaqu{\'i}n Mateo-Urdiales and Susana Fraile and Miguel Galarraga and Dharminder Chauhan and Fernando Fonseca San Miguel and Noopur Raje and Mercedes Garayoa},
Purpose: MLN9708 (ixazomib citrate), which hydrolyzes to pharmacologically active MLN2238 (ixazomib), is a next-generation proteasome inhibitor with demonstrated preclinical and clinical antimyeloma activity, but yet with an unknown effect onmyeloma bone disease. Here, we investigated its bone anabolic and antiresorptive effects in themyeloma setting and in comparisonwithbortezomib inpreclinical 
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