Cancer Therapy : Preclinical Dual HER 2 Targeting Impedes Growth of HER 2 Gene – Ampli fi ed Uterine Serous Carcinoma Xenografts

Purpose: Uterine serous carcinoma (USC) is an aggressive subtype of endometrial cancer that commonly harborsHER2 gene amplification. We investigated the effectiveness of HER2 inhibition using lapatinib and trastuzumab in vitro and in xenografts derived from USC cell lines and USC patient-derived xenografts. Experimental Design: Immunohistochemistry and FISH… (More)