Cancer Therapy: Preclinical Manipulating the Tumor Microenvironment Ex Vivo for Enhanced Expansion of Tumor- Infiltrating Lymphocytes for Adoptive Cell Therapy

Abstract

Purpose: Cultured tumor fragments from melanoma metastases have been used for years as a source of tumor-infiltrating lymphocytes (TIL) for adoptive cell therapy (ACT). The expansion of tumor-reactive CD8þ T cells with interleukin-2 (IL2) in these early cultures is critical in generating clinically active TIL infusion products, with a population of… (More)

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Cite this paper

@inproceedings{Chacon2015CancerTP, title={Cancer Therapy: Preclinical Manipulating the Tumor Microenvironment Ex Vivo for Enhanced Expansion of Tumor- Infiltrating Lymphocytes for Adoptive Cell Therapy}, author={Jessica Ann Chacon and Amod A. Sarnaik and Jie Chen and Caitlin Creasy and Charuta Kale and John Robinson and Jeffrey A. Weber and Patrick Hwu and Shari A Pilon-Thomas and Laszlo G. Radvanyi}, year={2015} }