Cancer Therapy: Preclinical Effective Anti-Neu–Initiated Antitumor Responses Require the Complex Role of CD4þ T Cells

Abstract

Purpose: Targeting oncogenic receptors with antibodies has been thought to suppress tumor growth mainly by interrupting oncogenic signals. Recently, the essential role for adaptive immunity, and CD8þ T cells in particular, has been established as a major factor for anti-HER2/neu–mediated tumor regression. However, the role of CD4þ T cells is still being… (More)

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