Cancer Therapy: Preclinical BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth

Abstract

Purpose: To investigate the roles of melanoma-associated macrophages in melanoma resistance to BRAF inhibitors (BRAFi). Experimental Design: An in vitro macrophage and melanoma cell coculture system was used to investigate whether macrophages play a role in melanoma resistance to BRAFi. The effects of macrophages in tumor resistance were examined by… (More)

Topics

6 Figures and Tables