Cancer Therapy: Preclinical BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth


Purpose: To investigate the roles of melanoma-associated macrophages in melanoma resistance to BRAF inhibitors (BRAFi). Experimental Design: An in vitro macrophage and melanoma cell coculture system was used to investigate whether macrophages play a role in melanoma resistance to BRAFi. The effects of macrophages in tumor resistance were examined by… (More)


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