Cancer Therapy: Preclinical ATM Kinase Inhibition Preferentially Sensitizes p53-Mutant Glioma to Ionizing Radiation


Purpose:Glioblastomamultiforme (GBM) is themost lethal formof brain cancerwith amedian survival of only 12 to 15 months. Current standard treatment consists of surgery followed by chemoradiation. The poor survival of patients with GBM is due to aggressive tumor invasiveness, an inability to remove all tumor tissue, and an innate tumor chemoand… (More)


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