Corpus ID: 4851883

Cancer Therapeutic Insights COX-2 and PPAR-g Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells

  title={Cancer Therapeutic Insights COX-2 and PPAR-g Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells},
  author={Robert M. Ramer and Katharina Heinemann and Jutta Merkord and Helga Rohde and Achim Salamon and Michael Linnebacher and Burkhard Hinz},
The antitumorigenicmechanismof cannabidiol is still controversial. This study investigates the role of COX2 and PPAR-g in cannabidiol’s proapoptotic and tumor-regressive action. In lung cancer cell lines (A549,H460) and primary cells from a patient with lung cancer, cannabidiol elicited decreased viability associated with apoptosis. Apoptotic cell death by cannabidiolwas suppressed byNS-398 (COX-2 inhibitor), GW9662 (PPAR-g antagonist), and siRNA targeting COX-2 and PPAR-g . Cannabidiol-induced… Expand

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