Cancer Stem Cells in Chronic Myelogenous Leukemia

@article{Marf2014CancerSC,
  title={Cancer Stem Cells in Chronic Myelogenous Leukemia},
  author={G. Marf{\'e} and C. D. Stefano},
  journal={Journal of Leukemia},
  year={2014},
  volume={2},
  pages={1-7}
}
Chronic Myeloid Leukaemia (CML) is a haematological malignancy that is identified by the presence of a fusion oncogene, BCR-ABL, which is a constitutive tyrosine kinase. The discovery of Tyrosine Kinase Inhibitors (TKIs) over that past decade has resulted in significantly improved survival rates and disease management in CML patients. However, a subpopulation of BCR-ABL1+ cells in the niche are found which exhibit stem cell-like features, such as self-renewal and quiescence. These CML stem… Expand
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